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. 2019 Sep 24;10:1182. doi: 10.3389/fphys.2019.01182

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Copyright © 2019 Premer, Wanschel, Porras, Balkan, Legendre-Hyldig, Saltzman, Dong, Schulman and Hare.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stromal derived factor-1α (SDF-1α) as a biomarker for endothelial function. (A) Schematic illustrating that mesenchymal stem cells (MSCs) secrete SDF-1α which stimulates the mobilization and function of endothelial progenitor cells (EPCs). (B) Allogeneic MSCs (n = 6) secrete significantly lower levels of SDF-1α compared to autologous MSCs (n = 11) 22.8 (7.2, 43.5) vs. 76.0 (63.7, 100.9) pg/mL, P = 0.0005^∗). (C) There was a significant inverse correlation between MSC SDF-1α secretion and the change in EPC-CFUs from baseline to 3-months post injection (n = 21, R = −0.7, P = 0.0004^∗). (D) Additionally, there was a correlation between the amount of SDF-1α secretion from cultured MSCs and the change in TNFα from baseline to 3-months post injection compared to (n = 15) (R = 0.7, P = 0.003^∗∗).