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. 2019 Sep 24;10:1182. doi: 10.3389/fphys.2019.01182

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Copyright © 2019 Premer, Wanschel, Porras, Balkan, Legendre-Hyldig, Saltzman, Dong, Schulman and Hare.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stromal derived factor-1α levels modulate the expression of TNFα expression in human coronary artery endothelial cells (HCAECs). (A) HCAECs exposed to low levels (20 ng) of SDF-1α express low levels of TNFα mRNA (0.7 ± 0.2) comparable to the PBS control, whereas those exposed to high levels (100 ng) express high levels of TNFα mRNA compared to control (2.1 ± 0.3, p = 0.005^∗∗). Furthermore, there is a significant difference comparing low dose vs. high dose (p = 0.004^∗) as well as comparing all three groups together (p = 0.0008). (B) HCAECs stimulated with lipopolysaccharide (LPS) significantly upregulate TNFα mRNA (Δ11.3 ± 3, p = 0.001^∗∗), and low dose (20 ng) of SDF-1α attenuate this elevation (Δ−4.8 ± 1.6, p = 0.03^∗). ^∗p < 0.001.