TABLE 1.
Baseline characteristics | Cell type | P-value | |
Allogeneic (n = 10) | Autologous (n = 11) | ||
Age at injection (years) | 58.3 (7.82) | 55.909 (10.65) | 0.99 |
Gender | |||
Male | 7 (70%) | 6 (54.5%) | 0.5 |
Female | 3 (30%) | 5 (45.5%) | 0.5 |
Ethnicity: Hispanic or Latino | 1 (10%) | 6 (54.5%) | 0.03∗ |
Race: White | 8 (80%) | 5 (45.5%) | 0.1 |
Race: Black | 1 (10%) | 0 (0%) | 0.3 |
History of hypertension | 4 (40%) | 2 (18.2%) | 0.3 |
New York heart association class | |||
Class I – No limitation | 2 (20%) | 4 (36.4%) | 0.4 |
Class II – Slight limitation of physical activity | 5 (50%) | 6 (54.5%) | 0.8 |
Class III – Marked limitation of physical activity | 3 (30%) | 1 (9.1%) | 0.2 |
History of congestive heart failure | 5 (50%) | 5 (45.5%) | 0.8 |
History of Valvular heart disease | 1 (10%) | 0 (0%) | 0.3 |
History of smoking | 7 (70%) | 4 (36.4%) | 0.3 |
History of diabetes | 0 (0%) | 1 (9.1%) | 0.3 |
Peak VO2 (mL/kg/min) | 17.23 ± 6.8 | 15.91 ± 5.94 | 0.6 |
Six minute walk test (meters) | 437.78 m ± 66.95 | 425.27 m ± 74.66 | 0.7 |
Forced expiratory volume in one second (%) | 2.43% (0.51) | 2.41% (0.9) | 0.9 |
MLHF: Median (IQR) | 44.6 (24.75–68) | 39 (21–67) | 0.6 |
LV size and function | |||
Ejection fraction (%) | 24.4% ± 5.52 | 21% ± 7.68 | 0.3 |
Left ventricular end diastolic volume (mL): Median (IQR) | 253.8 mL (225.2–272.45) | 193.2 mL (172.55–330.9) | 0.7 |
Left ventricular systolic volume (mL): Median (IQR) | 196.15 mL (171.73–219.95) | 164 mL (125.5–290.8) | 0.7 |
End diastolic diameter (cm): Median (IQR) | 7 cm (6.63–7.18) | 6.1 cm (5.85–7.65) | 0.9 |
Biomarkers | |||
EPC-CFUs | 3 ± 2 colonies | 5 ± 3 colonies | 0.08 |
TNFα | 24.5 ± 5.6 pg/mL | 25.3 ± 13.3 pg/mL | 0.9 |
Patient data are broken down by cell treatment, allogeneic (n = 10) vs. autologous (n = 11). Values are presented as n, n (%), or mean ± standard deviation. T-Tests and Chi-squared tests were used to compare groups, and statistically significant differences are indicated by bolding and an asterisk.