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. 2006 Jul 19;2006(3):CD001694. doi: 10.1002/14651858.CD001694.pub2

Comparison 1. Aerosolized furosemide vs. control.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Change in transcutaneous pO2 (mm Hg), patients > 3 weeks of age 1   WMD (Fixed, 95% CI) Subtotals only
1.1 1 hour after single dose 1 18 WMD (Fixed, 95% CI) ‐3.96 [‐8.77, 0.85]
1.2 2 hours after single dose 1 18 WMD (Fixed, 95% CI) 4.75 [‐4.54, 14.04]
2 Change in blood pH, 1 hour after 1 dose, patients > 3 weeks of age 1 16 WMD (Fixed, 95% CI) 0.0 [‐0.02, 0.02]
3 Change in compliance (ml/cm H2O/kg) 4   WMD (Fixed, 95% CI) Subtotals only
3.1 20 min after single dose, on second day, patients < 3 weeks of age 1 22 WMD (Fixed, 95% CI) ‐0.21 [‐0.38, ‐0.04]
3.2 30 min after a single dose, patients > 3 weeks of age 1 10 WMD (Fixed, 95% CI) ‐0.13 [‐0.40, 0.14]
3.3 1 hour after single dose, patients > 3 weeks of age 2 34 WMD (Fixed, 95% CI) 0.03 [‐0.01, 0.08]
3.4 2 hours after single dose, patients > 3 weeks of age 2 34 WMD (Fixed, 95% CI) 0.00 [‐0.03, 0.04]
3.5 Before therapy, on seventh day of therapy, patients > 3 weeks of age 1 10 WMD (Fixed, 95% CI) ‐0.21 [‐1.57, 1.15]
4 Change in resistance (cm/L/sec) 4   WMD (Fixed, 95% CI) Subtotals only
4.1 20 min after a single dose, on second day, patients < 3 weeks of age 1 22 WMD (Fixed, 95% CI) ‐10.0 [‐50.59, 30.59]
4.2 30 min after single dose, patients > 3 weeks 1 10 WMD (Fixed, 95% CI) 28.32 [‐28.34, 84.98]
4.3 1 hour after single dose, patients > 3 weeks of age 2 34 WMD (Fixed, 95% CI) ‐12.15 [‐28.23, 3.94]
4.4 2 hours after single dose, patients > 3 weeks 2 34 WMD (Fixed, 95% CI) ‐3.18 [‐17.68, 11.32]
4.5 2 hours after single dose, furosemide first 1 9 WMD (Fixed, 95% CI) 11.8 [‐8.26, 31.86]
4.6 2 hours after single dose, furosemide second 1 8 WMD (Fixed, 95% CI) ‐3.25 [‐34.85, 28.35]
4.7 Before therapy, on seventh day of therapy, patients > 3 weeks 1 10 WMD (Fixed, 95% CI) ‐1.88 [‐218.27, 214.51]
5 Change in tidal volume (ml/kg) 3   WMD (Fixed, 95% CI) Subtotals only
5.1 20 min after dose, on second day, patients < 3 weeks of age 1 22 WMD (Fixed, 95% CI) ‐0.9 [‐1.94, 0.14]
5.2 1 hour after single dose, patients > 3 weeks of age 2 34 WMD (Fixed, 95% CI) 1.86 [1.14, 2.59]
5.3 2 hours after single dose, patients > 3 weeks of age 2 34 WMD (Fixed, 95% CI) 1.11 [0.28, 1.94]
6 Change in minute ventilation (ml/kg/min) 20 min after dose, on 2nd day, > 3 weeks of age 1   WMD (Fixed, 95% CI) Subtotals only