Robbins 1993.
| Methods | Blinding of randomization: yes Blinding of intervention: yes Complete follow up: yes Blinding of outcome: yes Randomized clinical trial, parallel design No washout period documented | |
| Participants | Number of patients entered into the study: n=10 Mechanical ventilation Inclusion criteria: BPD Of 10 patients, five were allocated to each group. There was no significant difference between the two groups in any of the variables analyzed. Average birth weight was similar in furosemide‐treated patients and in those on placebo, 671±136 g and 786±242, g respectively. Mean gestational age was, respectively, 26.2±1.8 and 26.2±1.3 weeks, mean weight at entry 850±179 and 944±293 g, mean postnatal age 31±13 and 24±7 days, and postconceptional age 30.6±2.6 and 29.6±1.6 weeks, respectively. Peak inspiratory pressure was similar in both groups (20.2±1.8 vs 19.6±1.8 cm H2O), so were positive end expiratory pressure (5.2±1.1 and 5.0±1.0 cm) and FiO2 (0.41±0.25 and 0.41±20). | |
| Interventions | Aerosolized furosemide vs placebo Patients were randomly allocated to receive either aerosolized furosemide 1 mg/kg in 2 ml normal saline or placebo (normal saline) for seven days. The interval of administration is not stated in the abstract. | |
| Outcomes | Main outcome: pulmonary mechanics. There was no significant difference in compliance or in resistance between the two groups. | |
| Notes | Abstract form only; no information available about frequency of administration, type of nebulizer, flow, other medications. Pulmonary function tests (dynamic compliance and resistance) were obtained 15 minutes before aerosol, 30 minutes after the first dose and again on day 7 before the aerosol. | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Adequate sequence generation? | Unclear risk | Blinding of randomization: yes |
| Allocation concealment? | Low risk | Blinding of randomization: yes |
| Blinding? All outcomes | Low risk | Blinding of intervention: yes Blinding of outcome: yes |
| Incomplete outcome data addressed? All outcomes | Low risk | Complete follow‐up: yes |
| Free of selective reporting? | Unclear risk | Abstract form only |
| Free of other bias? | Unclear risk | Randomized clinical trial, parallel design No washout period documented |
± always precedes SD