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. 2019 Sep 26;14:7861–7878. doi: 10.2147/IJN.S215935

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© 2019 Bewersdorff et al.

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A reactive precursor particle approach gives access to a NG library with varying hydrophobicity and similar colloidal features.

Notes: Schematic synthesis of the NGs is depicted (A) based on precursor particles being subsequently amine functionalized (B). We used HPA that translates to PHPMA and four modified variants that each contained 80 mol-% HPA and 20 mol-% of a different hydrophobic group, ie hexylamine (HEXA-20), benzylamine (BENZA-20), linear dodecylamine (DODA-20) as well as an amine functionalized cholesteryl group (CHOLA-20).

Abbreviations: NG, nanogel; NGs, nanogels; HPA, 2-hydroxypropylamine; PHPMA, poly(N-(2-hydroxypropyl)methacrylamide); FITCA, amine functionalized fluorescein; EGDMA, ethylene glycol dimethacrylate.