Minnesota 2000.

Methods	See Mandel et al 1993 and 1999 (Update of Minnesota study) Follow‐up for vital statistics complete for 91.3% (Agrp), 91.7% (Bgrp) and 91.2% (Cgrp); 95% complete for all groups through to Year 17 Death certificates missing for 3 of the 18,873 people who were known to have died during 18 year follow‐up
Participants	See Mandel et al 1993 and 1999
Interventions	See Mandel et al 1993 and 1999
Outcomes	Colorectal cancer incidence at 18 years follow‐up Number of CRC cases: Agrp 417 (32/1000), Bgrp 435 (33/1000), Cgrp 507 (39/1000) Agrp PPV for CRC: ranged from 0.87% for one positive slide and 4.53% for six slides Bgrp PPV for CRC: ranged from 1.12% for one positive slide and 6.13% for six slides Agrp PPV for adenomatous polyps =1cm: ranged from 5.99% for one positive slide and 7.87% for six slides Bgrp PPV for adenomatous polyps =1cm: ranged from 6.86% for one positive slide and 10.08% for six slides Mortality reduction: see Mandel et al 1999
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate