Comparison 1. Exercise versus usual care.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 ALSFRS scores at 3 months	2	43	Mean Difference (IV, Fixed, 95% CI)	3.21 [0.46, 5.96]
2 SF‐36 scores at 3 months	1	18	Mean Difference (IV, Fixed, 95% CI)	2.70 [‐3.10, 8.50]
3 Physical Function (SF‐36) subscale scores at 3 months	1	25	Mean Difference (IV, Fixed, 95% CI)	3.76 [‐1.07, 8.59]
4 Physical Role (SF‐36) subscale scores at 3 months	1	25	Mean Difference (IV, Fixed, 95% CI)	0.52 [‐0.72, 1.76]
5 Bodily Pain (SF‐36) subscale scores at 3 months	1	25	Mean Difference (IV, Fixed, 95% CI)	‐0.09 [‐1.40, 1.22]
6 General Health (SF‐36) subscale scores at 3 months	1	24	Mean Difference (IV, Fixed, 95% CI)	1.02 [‐2.82, 4.86]
7 Vitality (SF‐36) subscale scores at 3 months	1	25	Mean Difference (IV, Fixed, 95% CI)	‐1.93 [‐4.55, 0.69]
8 Social Function (SF‐36) subscale scores at 3 months	1	25	Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐1.69, 1.29]
9 Emotional Role (SF‐36) subscale scores at 3 months	1	25	Mean Difference (IV, Fixed, 95% CI)	0.69 [‐0.16, 1.54]
10 Mental Health (SF‐36) subscale scores at 3 months	1	25	Mean Difference (IV, Fixed, 95% CI)	0.66 [‐0.86, 2.18]
11 Physical Health summary scores	1	25	Mean Difference (IV, Fixed, 95% CI)	5.0 [‐4.46, 14.46]
12 Mental Health summary scores	1	25	Mean Difference (IV, Fixed, 95% CI)	‐0.79 [‐5.90, 4.32]
13 FSS scores at 3 months	2	43	Mean Difference (IV, Fixed, 95% CI)	‐6.25 [‐13.82, 1.31]
14 MMT scores at 3 months	1	18	Mean Difference (IV, Fixed, 95% CI)	‐10.90 [‐23.56, 1.76]
15 MVIC Upper Extremity	1	22	Mean Difference (IV, Fixed, 95% CI)	‐1.48 [‐4.78, 1.82]
16 MVIC Lower Extremity	1	20	Mean Difference (IV, Fixed, 95% CI)	2.51 [‐2.05, 7.07]