Table 3.
Inhibition of Kv1.3 channels by non-prenylated and prenylated flavonoids and substituted stilbenes.
| Name of the compound | Model system used for the study | EC50 value and magnitude of the inhibitory effect | References |
|---|---|---|---|
| Genistein | Human T lymphocytes | EC50 = (10–40) μM Maximal inhibition−77% at 80 μM concentration |
(53) |
| Resveratrol | Human T lymphocytes | EC50 = 40 μM Maximal inhibition−82% at 200 μM concentration |
(54) |
| Naringenin-4′, 7-dimethylether | Human T lymphocytes | EC50 not estimated Inhibition of 96% of the currents at 30 μM Concentration |
(55) |
| Naringenin-7-methylether | Human T lymphocytes | EC50 not estimated Inhibition of 71% of the currents at 30 μM concentration |
(55) |
| Tetramethoxy- piceatannol | Human T lymphocytes | EC50 not estimated Inhibition of 69% of the currents at 30 μM concentration | (55) |
| Acacetin | Human T lymphocytes and Jurkat T cells | EC50 = 21 μM and 4 μM for the peak and end-of-the-pulse currents, respectively. Maximal inhibition−90% of end-of-the-pulse currents at 100 μM concentration. Inhibition of 50% of peak ramp currents at 30 μM concentration |
(56, 57) |
| Chrysin | Jurkat T cells | Inhibition of 46% of peak ramp currents at 30 μM concentration | (57) |
| 8-Prenyl-naringenin (8-PR) | Human T lymphocytes and Jurkat T cells | EC50 = 3 μM Maximal inhibition−100% at 10 μM concentration |
(58) |
| 6-Prenyl-naringenin (6-PR) | Jurkat T cells | EC50 = 6 μM Maximal inhibition−88% at 30 μM concentration |
(57) |
| Xanthohumol | Jurkat T cells | EC50 = 3 μM Maximal inhibition−87% at 30 μM concentration | (59) |
| Isoxanthohumol | Jurkat T cells | EC50 = 8 μM Maximal inhibition−87% at 30 μM concentration | (59) |