Comparison 3.
IM OLANZAPINE vs BENZODIAZEPINES
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Death | 1 | 150 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2 Global effect: 1. Did not respond ‐ by 2 hours (>=40% change on PANSS‐EC) | 2 | 355 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.92 [0.66, 1.30] |
| 3 Global effect: 2. Average change score ‐ by 24 hours (CGI‐severity, low score = poor) | 2 | 281 | Mean Difference (IV, Random, 95% CI) | ‐0.07 [‐0.28, 0.13] |
| 4 Mental state: Average mania change score ‐ by 24 hours (YMRS, low score = poor) | 1 | 145 | Mean Difference (IV, Random, 95% CI) | ‐0.53 [‐3.44, 2.38] |
| 5 Behaviour: 1. Leaving the study early ‐ by 24 hours | 2 | 355 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.50 [0.21, 1.16] |
| 6 Behaviour: 2. Requiring addtional IM injection ‐ by 24 hours | 2 | 355 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.68 [0.49, 0.95] |
| 7 Behaviour: 3a. Average behaviour change score (CMAI, low score = poor) | 1 | Mean Difference (IV, Fixed, 95% CI) | Subtotals only | |
| 7.1 by 2 hours | 1 | 134 | Mean Difference (IV, Fixed, 95% CI) | 0.82 [‐0.44, 2.08] |
| 7.2 by 24 hours | 1 | 134 | Mean Difference (IV, Fixed, 95% CI) | ‐0.54 [‐1.74, 0.66] |
| 8 Behaviour: 3b. Average behaviour change score (PANSS‐Excited component, low score = poor) | 2 | Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 8.1 by 2 hours | 2 | 283 | Mean Difference (IV, Random, 95% CI) | ‐1.63 [‐4.24, 0.98] |
| 8.2 by 24 hours | 2 | 283 | Mean Difference (IV, Random, 95% CI) | ‐1.79 [‐4.05, 0.46] |
| 9 Adverse event: 1. Any treatment emergent adverse event ‐ by 24 hours | 1 | 150 | Risk Ratio (M‐H, Random, 95% CI) | 0.62 [0.43, 0.89] |
| 10 Adverse event: 2. EPS ‐ requiring anticholinergic medication | 1 | 150 | Risk Ratio (M‐H, Random, 95% CI) | 1.16 [0.38, 3.58] |
| 11 Adverse event: 3. Other ‐ by 24 hours | 2 | Risk Ratio (M‐H, Random, 95% CI) | Subtotals only | |
| 11.1 accidental injury | 1 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.60 [0.27, 1.31] |
| 11.2 dizzyness | 1 | 150 | Risk Ratio (M‐H, Random, 95% CI) | 1.03 [0.44, 2.39] |
| 11.3 ECG abnormality | 1 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.85 [0.35, 2.06] |
| 11.4 headache | 1 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.81 [0.35, 1.85] |
| 11.5 hypertension | 1 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.61 [0.26, 1.39] |
| 11.6 nausea | 1 | 150 | Risk Ratio (M‐H, Random, 95% CI) | 0.15 [0.03, 0.68] |
| 11.7 somnolence | 2 | 355 | Risk Ratio (M‐H, Random, 95% CI) | 0.64 [0.36, 1.15] |
| 11.8 vasodilation | 1 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.78 [0.32, 1.92] |
| 11.9 vomiting | 1 | 150 | Risk Ratio (M‐H, Random, 95% CI) | 0.09 [0.01, 0.69] |