Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 24;13:431. doi: 10.3389/fncel.2019.00431

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Nagendran and Taylor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Dantrolene or Xestospongin C applied at the time and location of axotomy prevent retrograde enhancement of presynaptic release rate. (A) FM unloading curves at 48 h following application of vehicle or Dantrolene (20 μM) or Xestospongin C (1 μM) to axons for 1 h during axotomy. Uninjured control: n = 1076 puncta; Axot. + Veh: n = 893 puncta; Axot. + Dan: n = 1136 puncta; Axot. + Xes: n = 2234; 5 chambers per condition over two experiments. Two-way ANOVA, Bonferroni post hoc test. (B) FM decay time constant (τ) for puncta with τ < 360 s (Uninj. control: n = 1045; Axot. + Veh: n = 857; Axot. + Dan: n = 1058; Axot. + Xes: n = 2139). Unpaired two-tailed t-test. Each condition includes 5 chambers combined over 2 independent experiments. Error bars, SEM. ^∗∗p < 0.005.