Thome‐Souza 2007

Methods	A single‐centre, non‐randomised, uncontrolled, prospective before and after study (Brazil) Baseline period: Not reported Treatment period: Mean 25.8 months (range 12‐78)
Participants	36 children and adolescents with focal epilepsy and diagnosis of depression 19 females and 17 males Aged 5 to 18 years, mean: 12.7 years
Interventions	Sertraline up to 200 mg per day, mean dose 111.5 mg per day (50 to 200 mg) Fluoxetine up to 80 mg per day, mean dose 45.7 mg per day (20 to 80 mg)
Outcomes	1) Seizure severity 2) Improvement in depressive symptoms 3) Adverse effects
Notes	No drop‐outs
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	No randomisation methods used
Allocation concealment (selection bias)	High risk	No methods for concealing allocation used
Blinding of participants and personnel (performance bias) All outcomes	High risk	Participants not blinded; unclear about other study personnel. Rated 4 on scale for risk of bias
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Unclear whether outcome assessors blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data
Selective reporting (reporting bias)	Low risk	Outcomes stated in methods section of report are present in the results. No protocol available. Rated 2 on scale for risk of bias
Other bias	Low risk	No other risk of bias detected. Rated 1 on scale for risk of bias
Confounding variables	High risk	Some confounding variables considered but not adjusted for in the analysis. Rated 4 on scale for risk of bias