| Methods | Single‐centre, randomised trial of venlafaxine versus no treatment (China) Baseline period: Not reported Treatment period: 8 weeks |
|
| Participants | 64 people with epilepsy (presumed genetic or cause unknown) and depression 39 males and 25 females Aged 7 to 60 years (mean 27 years) | |
| Interventions | Venlafaxine 25 mg to 75 mg/day (n = 32) No treatment (n = 32) |
|
| Outcomes | 1) Change in HAMD‐21 scores 2) Adverse events |
|
| Notes | No drop‐outs | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Methods for generation of random sequence are not detailed in the report |
| Allocation concealment (selection bias) | Unclear risk | Methods for allocation are not detailed in the report |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | No details of blinding methods in the report |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear whether outcome assessor blinded |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | No missing data |
| Selective reporting (reporting bias) | Low risk | Outcomes stated in methods section of report are present in the results. No protocol available |
| Other bias | Unclear risk | Insufficient details in report to judge the influence of other bias |
| Confounding variables | Low risk | NA |
CCMD‐3: Chinese Classification of Mental Disorders
HAMD: Hamilton Rating Scale for Depression ITT: Intention‐To‐Treat MADRS: Montgomery–Åsberg Depression Rating Scale NA: Not Applicable