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. 2019 Sep 29;12:2516865719879436. doi: 10.1177/2516865719879436

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Experimental workflow of sampled species with a corresponding intrachromosomal heatmap and 3D genome model: (A) simplified models of 3 species studied in the experiment; (B) overview of the in situ Hi-C protocol; (C) intrachromosomal contact count heatmaps corresponding to species shown in (A), with domain-like structure shown in P. falciparum chr7 due to internal var genes; and (D) PASTIS 3D models of entire genomes corresponding to species shown in (A), using a gradient of dark blue to white to represent areas of low to high gene expression, respectively. Yellow spheres represent centromeres, and telomeres are shown as red spheres.