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. 2019 Sep 4;9(9):190095. doi: 10.1098/rsob.190095

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — miR-181a-5p is a direct target of MALAT1 in gastric cancer. (a) MGC-803 cells treated with or without siRNA of MALAT1 were lysed and the miRNA levels were determined by qPCR. n = 3 independent experiments, data are presented as the mean ± s.d. and ***p < 0.001 compared with the scramble group. (b) The schematics show the interaction between hsa-miR-181a-5p and MALAT1. (c) The miR-181a-5p expression levels in 70 pairs of gastric adenocarcinoma and corresponding non-tumour normal tissues were determined by qRT-PCR. Results are represented as the mean ± s.d. and ***p < 0.001. (d) Spearman's correlation analysis was performed between has-miR-181a-5p and MALAT1 expression levels (R² = 0.2083, p < 0.001).