Table 2. The Top 20 Differentially Expressed Genes in Invasive PAs Compared with Noninvasive PAs (|FC|≥2, FDR <0.1).
| Gene | Gene description | Log2FC | FDR |
|---|---|---|---|
| Up-regulated genes | |||
| ZCCHC12 | Zinc finger CCHC-type containing 12 | 2.81 | 0.047 |
| NEFM | Neurofilament, medium polypeptide | 2.54 | 0.073 |
| SCD | Stearoyl-CoA desaturase | 2.42 | 0.055 |
| DCX | Doublecortin | 2.24 | 0.026 |
| EPHA7 | EPH receptor A7 | 2.17 | 0.026 |
| SLC24A2 | Solute carrier family 24 member 2 | 2.12 | 0.040 |
| FRMPD1 | FERM and PDZ domain containing 1 | 2.12 | 0.036 |
| SLC8A2 | Solute carrier family 8 member A2 | 2.01 | 0.059 |
| RNF157 | Ring finger protein 157 | 1.98 | 0.034 |
| NRG1 | Neuregulin 1 | 1.96 | 0.001 |
| SLC32A1 | Solute carrier family 32 member 1 | 1.88 | 0.056 |
| CLDN9 | Claudin-9 | 1.75 | 0.041 |
| LRRN2 | Leucine rich repeat neuronal 2 | 1.66 | 0.017 |
| SCG2 | Secretogranin II | 1.65 | 0.041 |
| NDRG4 | N-myc downstream-regulated gene 4 protein | 1.62 | 0.034 |
| IL5RA | Interleukin 5 receptor subunit alpha | 1.62 | 0.014 |
| FGF12 | Fibroblast growth factor 12 | 1.62 | 0.031 |
| NLRP1 | NLR family pyrin domain containing 1 | 1.55 | 0.089 |
| EEF1A2 | Eukaryotic translation elongation factor 1 alpha 2 | 1.54 | 0.020 |
| LANCL3 | NDRG family member 4 LanC like 3 | 1.53 | 0.049 |
| Down-regulated genes | |||
| MGP | Matrix Gla protein | −5.22 | <0.001 |
| DCN | Decorin | −5.13 | <0.001 |
| IGKC | Immunoglobulin kappa constant | −4.81 | <0.001 |
| C1S | Complement C1s | −4.58 | <0.001 |
| C1R | Complement C1r | −4.44 | <0.001 |
| TGM2 | Transglutaminase 2 | −4.41 | <0.001 |
| COL3A1 | Collagen type III alpha 1 chain | −4.17 | 0.012 |
| IGFBP6 | Insulin like growth factor binding protein 6 | −3.97 | <0.001 |
| AGR2 | Anterior gradient 2, protein disulfide isomerase family member | −3.94 | <0.001 |
| SERPING1 | Serpin family G member 1 | −3.86 | <0.001 |
| BGN | Biglycan | −3.81 | 0.001 |
| CYBRD1 | Cytochrome b reductase 1 | −3.80 | <0.001 |
| IGFBP4 | Insulin like growth factor binding protein 4 | −3.66 | <0.001 |
| AEBP1 | AE binding protein 1 | −3.66 | <0.001 |
| IFITM1 | Interferon induced transmembrane protein 1 | −3.65 | 0.001 |
| FAT1 | FAT atypical cadherin 1 | −3.60 | 0.001 |
| CFH | Complement factor H | −3.57 | <0.001 |
| COL6A2 | Collagen type VI alpha 2 chain | −3.53 | 0.004 |
| ANXA1 | Annexin A1 | −3.47 | 0.001 |
| TAGLN | Transgelin | −3.43 | <0.001 |
PA, pituitary adenoma; FC, fold change; FDR, false discovery rate.