Table 3. GC classification by single patient classifier.
| Subtypes | Classifier genes | Biological characteristics | Clinicopathological characteristics | Clinical significance |
|---|---|---|---|---|
| Immune | GZMB | Immune/inflammatory gene signature | • EBV GC predominant | • Favorable prognosis |
| WARS | • Intestinal type | • Unresponsive to CTx | ||
| • Older age | ||||
| Epithelial | CDX1 | Proliferative gene signature | • EBV negative GC | • Responsive to CTx |
| • MSS/MSI-L | ||||
| • Younger age | ||||
| Stem-like | SFRP4 | Stem-ness/stromal gene signature | • TCGA GS predominant | • Unfavorable prognosis |
| • Diffuse type | ||||
| • Younger age |
EBV = Epstein-Barr virus; GC = gastric cancer; CTx = chemotherapy; MSS = microsatellite stable; MSI-L = microsatellite instability-low; TCGA = The Cancer Genome Atlas; GS =genomically stable.