Table 4. Representative cytokines of each classification.
| Representative cytokine | Th1/2 | Receptor structure | Example* |
|---|---|---|---|
| IL-2† | Th1 | Type 1, common r-chain† | IL-7,9,15,21 |
| IL-6 | Th1 | Type 1, IL-6 like cytokines | IL-11,30 |
| IL-12 | Th1 | Type 1, IL-12 subfamilies | IL-23, 27, 35 |
| IL-17 | Th1 | Type 1, IL-17R | |
| TNF-α | Th1 | Type 1, TNF | TNF-β |
| IFN-γ | Th1 | Type 2, IFN | |
| IL-8 | Th1 | Chemokine R | |
| IL-3 | Th1 & Th2 | Type 1, common-b-chain | IL-5, GM-CSF |
| IL-4† | Th2 | Type 1, common r-chain† | IL-13 |
| IL-1 | Th2 | Type 1, IG | IL-18, 33, 36, 37, 38 |
| IL-10 | Th2 | Type 2, IL-10 subfamily | IL-19, 20, 22, 24, 26 |
| MCP-1 | Th2 | Chemokine R | |
| TGF-β | Th2 | TGF receptor family |
IL = interleukin; Th = T helper; TNF = tumor necrosis factor-alpha; IFN, interferon; GM-CSF = granulocyte-macrophage colony-stimulating factor; MCP-1 = monocyte chemoattractant protein-1; TGF = transforming growth factor.
*Examples according to receptor structure; may not show the same Th1/2 balance as representative cytokines; †IL-2 and IL-4 share the same receptor structure but show opposite Th1/2 balance.