Figure 1. Major druggable targets expressed as proteins or glycoproteins and functioning as receptors, ligands, channels, mitotic protein kinases or nuclear receptors.

TIM-3 = T cell immunoglobulin and mucin-domain containing-3; PD-1 = programmed cell death protein 1; PD-L1 = programmed death-ligand 1; Hh = hedgehog; VEGFR2 = vascular endothelial growth factor receptor 2; FGFR = fibroblast growth factor receptor; EGFR = epidermal growth factor receptor; GPNMB = glycoprotein non-metastatic B; Trop-2 = trophoblast antigen 2; AR = androgen receptor; CSF1R = colony stimulating factor 1 receptor; FZD = frizzled.