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. 2019 Sep 9;9(9):467. doi: 10.3390/biom9090467

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Prognostic impacts of proteasome gene alterations on overall (A) and metastasis-free (B) survival in colorectal cancer (CRC). The prognostic impact of the miR-21-downregulated proteasome gene signature (PSME3, PSMA1, PSMA2, PSMA3, PSMB2, PSMB3, PSMB4, PSMB5, PSMB8, PSMB10, PSMC2, PSMC3, PSMC4, PSMC5, PSMC6, PSMD3, PSMD4, PSMD11, PSME1, PSMF1, and PSMD6) in CRC was evaluated using the PROGgeneV2 database (http://www.compbio.iupui.edu/proggene/). Two CRC patient datasets (GSE28722 and GSE28814) were employed to generate the Kaplan–Meier survival plots. Patients with high (n = 61 or 63) and low (n = 61 or 62) miR-21 expression in GSE28722 and GSE28144, respectively, were bifurcated at the median value. HR, hazard ratio; PVAL, p value.