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. 2019 Aug 29;11(9):1271. doi: 10.3390/cancers11091271

Figure 2.

Figure 2

TMB as Biomarker in non-small cell lung cancer. The cut-off for high TMB population for the Oncomine TML panel (OTML) is set to 9.39, while the cut-off for high TMB population in the FoundationOne test (FO) is set to 15 in the NSCLC population. (A) The mean TMB is higher in the DCB cohort than in the NDB cohort. (B) The ROC curves with their respective areas under the curve (AUC) are computed on all available data for each test individually. The 95% confidence interval is indicated in brackets. (C) The ROC curves with their AUC in the subpopulation where the TMB was correctly assessed using both panels in the same sample cohort allowing direct comparison of the different TMB panels. The 95% confidence interval is indicated in brackets. (D) The ratio of NSCLC patients with a durable clinical benefit (DCB) is greater than the patients with no durable benefit (NDB) in the cohort with high TMB. The number of samples (N) used for calculation is mentioned on each figure.