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. 2019 Sep 6;11(9):2129. doi: 10.3390/nu11092129

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Relationship between leptin and NO in lipid metabolism. Leptin modulates NO production in WAT through PKA and MAP kinase activation, being an important regulator signal of leptin-induced lipolysis. In peripheral tissues, leptin induces fatty acid oxidation, inhibiting lipid accumulation, decreasing lipogenesis, and reducing lipotoxicity associated with non-oxidative fatty acid metabolism. MAPK, mitogen-activated protein kinase; NO, nitric oxide; PKA, protein kinase A; WAT, white adipose tissue.