Figure 3.

HSP90 functions as a mediator of many oncogenic and signaling pathways [21]. Several oncogenic proteins (shown in red) require HSP90 chaperonage for their proper folding and stabilization. For instance, HSP90 impacts the activity and/or function of receptor tyrosine kinases, serine-threonine kinases, steroid receptors, Src family members, telomerases and cell cycle proteins. Other distinctive pathways regulated by HSP90 are illustrated in different colors, including apoptotic pathway (brown), JAK/STAT pathway and cell-adhesion and Wnt-signaling (purple and light brown).