Table 1.
Regulation of Rho GTPases activity by post-translational modifications of Rho GDP dissociation inhibitor (RhoGDI).
| PTMs | Regulator | Target Site | Effects | Refs. |
|---|---|---|---|---|
| Phosphorylation | Src PAK1 PKCα PKA FER |
Tyr27, Tyr156 Ser101, Ser174 Ser34, Ser96 Ser174 ND |
Promotes release of RhoA, Rac1, and Cdc42 Promotes release of Rac1 Promotes release of RhoA and RhoG Induces the complex formation with RhoA Prevents the interaction with Rac1 |
[45,47,48,49,50,53] |
| Dephosphorylation | PTP-PEST PPM1B |
Tyr156 Ser174 |
Inactivation of Rac1 and Cdc42 Inactivation of RhoA, Rac1, and Cdc42 |
[51,56] |
| Sumoylation | ND | Lys138 | Increases the binding to RhoA, Rac1 and Cdc42 | [59] |
| Ubiquitination | GRAIL | ND | Inhibits RhoA activation | [61] |
| Acetylation | p300, pCAF | Lys127, Lys141 | Promotes release of RhoA | [62,63] |
| Oxidation | ND | ND | Promotes RhoA activation | [64] |
ND, not determined.