Table 1.

Effect of S-nitrosylation of proteins associated with Tumor Microenvironment.

Protein Name	Effect of S-Nitrosylation	Consequence	Ref.
Bcl-2	Inhibition of ubiquitination (activation)	Anti-apoptosis	[18]
Caspases	Inhibition of caspase activity	Anti-apoptosis	[19,119]
Fas Receptor	Promote Fas ligand mediated apoptosis	Apoptosis	[18]
GAPDH	Nuclear translocation	Apoptosis	[105]
TG2	Inhibition of activity	Tumor suppression	[120,121]
MGMT	Inhibition of DNA repair activity	DNA damage & apoptosis	[18,122,123]
OGG1	Inhibition of DNA repair activity	DNA damage & apoptosis	[122]
HDAC2	Inhibition of deacetylase activity	Histone acetylation	[124,125]
MMPs	Activation (low level) Inhibition (high level)	Tumor progression Tumor suppression	[126,127]
Caveolin-1	Inhibition of proteasomal degradation	Tumor progression	[128]
c-Src	Activation	Tumor progression	[18]
Β-catenin	Proteasomal degradation	Tumor suppression	[129]
HDM2	Inhibition of binding to p53	Tumor suppression	[130]
HIF-1α	Stabilization of activity	Pro-angiogenesis	[14,18]
MAT	Inactivation of enzyme activity	Tumor suppression	[82,131]
NF-kB	Inhibition of activity	Tumor suppression	[14]
PTEN	Inhibition of activity	Tumor progression	[18,132]
Ras	Activation	Tumor progression	[133]