Table 4.
Alterations and roles of α(1,2) fucosylation in tumors.
| Cancer Type | Alterations and Roles of α(1,2) Fucosylation | Refs |
|---|---|---|
| Melanoma | • α(1,2) fucosylation inhibits tumor formation | [14,15,87] |
| • 25% of melanoma cell lines lack FUT1 expression | [11,94] | |
| • FUT1 expression is decreased in tumors | [14,95] | |
| • α(1,2) fucosylation inhibits invadopodia & invasion | [87] | |
| Oral/Head & Neck | • α(1,2) fucosylation inhibits tumor formation | |
| • FUT1 expression is decreased in tumors | [16] | |
| • α(1,2) fucosylation high in tumors, lost at invading front | ||
| Gastric | • α(1,2) fucosylation inhibits tumor formation | [89] |
| Hepatocellular | • α(1,2) fucosylation inhibits tumor formation | [17,63] |
| • FUT1 expression is decreased in tumors | [63] | |
| Ovarian | • α(1,2) fucosylation is increased by FUT1 upregulation | [96] |
| Prostate | • α(1,2) fucosylation is increased by FUT1 upregulation | [81,85] |
| Colorectal | • α(1,2) fucosylation increased in tumor tissues | [15,97,98,99] |
| • FUT1 expression attenuates adhesion and metastasis to the liver | ||
| Pancreatic | • α(1,2) fucosylation is decreased in primary tumor tissues. | [86,100,101,102] |
| • FUT1 expression decreases metastatic adhesion | [86] | |
| Breast | • FUT1 mRNA is upregulated in adriamycin-resistant cells | [92] |
| • α(1,2) fucosylation regulates autophagic flux | [91] | |
| Bladder | • α(1,2) fucosylation promotes cell adhesion | [93] |
| Epidermoid | • α(1,2) fucosylation promotes cell proliferation | [90] |