Table 7.
Summary of studies that have manipulated FUTs and documented biological outcomes in tumor cell lines.
| Cancer Type | Results of FUT Manipulation in Cell Lines | Reference |
|---|---|---|
| Breast | • FUT4 overexpression promoted invasion & tumor growth | [130] |
| • FUT8 knockdown inhibited tumor growth & metastasis | [5] | |
| • FUT8 overexpression promoted EMT and invasion | [5] | |
| Melanoma | • FUT1 overexpression inhibited metastasis | [15] |
| • FUT1 overexpression inhibited invadopodia & invasion | [87] | |
| • FUT4 knockdown inhibited proliferation & tumor growth | [129] | |
| • FUT8 knockdown decreased invasion, tumor growth, & metastasis | [95] | |
| Oral/Head & Neck | • FUT1 overexpression suppressed cell growth & invasion; knockdown increased cell growth &invasion | [16] |
| • FUT3 overexpression promoted invasion | [125] | |
| • FUT6 overexpression enhanced adhesion & invasion | [125] | |
| Liver | • FUT1 overexpression suppressed adhesion | [17] |
| • FUT6 overexpression increased proliferation, colony formation, & tumor growth | [113] | |
| • FUT4, 6, & 8 overexpression amplified drug resistance | [131] | |
| • FUT4, 6, & 8 knockdown suppressed drug resistance and inhibited tumor growth | [131] | |
| • FUT7 silencing decreased adhesion, migration, & invasion | [134] | |
| • FUT7 overexpression amplified proliferation | [138] | |
| • FUT8 knockdown inhibited invasion, migration, & proliferation | [140] | |
| • FUT8 overexpression suppressed proliferation, tumor formation, & metastasis | [164] | |
| Ovarian | • FUT1 overexpression increased proliferation adhesion, invasion, metastasis & resistance | [108,205] |
| • FUT1 overexpression increased colony formation & proliferation | [103] | |
| Prostate | • FUT3 overexpression amplified adhesion | [133] |
| • FUT6 overexpression increased migration & metastasis | [133] | |
| • FUT7 overexpression enhanced adhesion | [133] | |
| • FUT8 knockdown decreased migration | [153] | |
| • FUT8 overexpression increased motility | [153] | |
| Colorectal | • FUT1 overexpression suppressed adhesion | [97] |
| • FUT1 overexpression inhibited metastasis | [109] | |
| • FUT3 & 6 knockdown decreased adhesion, invasion, & migration | [127] | |
| • FUT5/6 knockdown inhibited migration and proliferation | [206] | |
| Pancreatic | • FUT1 overexpression suppressed adhesion and metastasis | [86] |
| • FUT3 knockdown decreased migration, adhesion, and metastatic colonization | [116,207] | |
| Gastric | • FUT3 knockdown decreases migration | [119] |
| • FUT5 knockdown inhibited adhesion & migration | [119] | |
| • FUT8 overexpression suppressed proliferation, tumor formation, & metastasis | [146] | |
| Lung | • FUT4 overexpression promoted EMT | [208] |
| • FUT7 overexpression increased adhesion, colony formation, invasion, & migration | [137] | |
| • FUT8 knockdown decreased proliferation & colony formation | [52] | |
| • FUT8 overexpression suppressed proliferation, tumor formation, & metastasis | [163] |