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. 2019 Sep 9;20(18):4427. doi: 10.3390/ijms20184427

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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µCT-derived measurement of the fifth lumbar vertebral body cancellous bone from Cre-negative (white bars) and ^10kbDmp1-Cre-positive (grey bars) Twist1^f/f mice at 16 wk of age, treated with or without sclerostin antibody (Scl-Ab) for 6 wk prior to sacrifice. (A) Representative 3D cutaway reconstructions of the fifth lumbar vertebra in A-P view (top row) and S-I view (bottom row). Female mice are in the top of the panel, males in the bottom. Quantitative differences in lumbar vertebra 5 (LV₅) (B) trabecular bone volume fraction (BV/TV), (C) trabecular thickness (Tb.Th), (D) trabecular bone mineral content (Tb.BMC), (E) and trabecular separation (Tb.Sp) are shown for female (left side of each panel) and male (right side of each panel) mice. Data were tested for significance using two-way ANOVA within sex, with Twist1 status and antibody as the main effects (plus interaction), which are reported in the corner or base of each sex grouping; n = 8–11/group.