Skip to main content
. 2019 Aug 30;8(9):1012. doi: 10.3390/cells8091012

Figure 1.

Figure 1

Construction and representation of a heterogeneous network with three different nodes. (a) LncRNA network (LncNet) and its adjacency matrix L were constructed by calculating the functional similarity of the lncRNAs according to their associated diseases. (b) Calculation of the functional similarity of the lncRNAs based on their related diseases and construction of miRNA network (MirNet) and the adjacency matrix M. (c) Establishment of the connexion between LncNet and disease network (DisNet) based on known lncRNA-disease associations and construction of the adjacency matrix A. (d) Connexion of LncNet and MirNet according to known interactions between lncRNAs and miRNAs and construction of the adjacency matrix B. (e) Connexion of the miRNAs and diseases according to known miRNA-disease associations and construction of the adjacency matrix C. (f) Computation of the similarities based on the DAGs of the diseases and construction of DisNet and the adjacency matrix D. (g) LncNet, DisNet, MirNet, and the connexions among them were used to construct the heterogeneous network LncDisMirNet and its adjacency matrix U.