Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 13;20(18):4530. doi: 10.3390/ijms20184530

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

A working hypothesis for the syncytialization of the sheep placenta. Mononuclear trophoblast cells fuse with one-another to become multinucleated TGCs. Large numbers of TGCs migrate to insert themselves between the uterine LE cells that are simultaneously undergoing apoptosis. TGCs then engulf LE cells and carry them to the stroma for elimination by immune cells. The remaining TGCs then fuse with each other to form an extensive trophoblast syncytial layer that fills spaces left by removal of uterine LE and form the interface between caruncles and cotyledons in placentomes of the functional synepitheliochorial placenta of sheep.