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. 2019 Aug 21;11(9):1218. doi: 10.3390/cancers11091218

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Modes of action of ectodomain proteins. Schematic representation of the various autocrine, paracrine and/or juxtacrine modes of action by which biologically active processed ADAM17 substrates (i.e., ectodomains) act on cells.