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Overview of the genetic manipulation strategy used to create the Adam17ex/ex mice. Shown are the exon regions for both wild-type (WT) and hypomorphic (ex) Adam17 alleles. For generating the ex allele, the neomycin resistance gene in the targeting cassette is depicted “Neo”, along with the introduced stop codon in the artificial exon 11 (E11a). Arrows depict PCR primers use to amplify and distinguish specific regions of the WT and ex alleles.
