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. 2019 Aug 21;11(9):1218. doi: 10.3390/cancers11091218

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Overview of ADAM17 activity regulation. Schematic representation of the expression of immature proADAM17 polypeptide in the endoplasmic reticulum, following which it is transported to the golgi apparatus via iRhom-mediated mechanism. The proADAM17 then undergoes a maturation step, which requires its inhibitory N-terminal prodomain to be cleaved off by furin protease, following which, mature ADAM17 is transported to the cell membrane. The activity of ADAM17 can also be inhibited by TIMP3 or activated via phosphorylation by MAPKs, PI3K and PKC.