Table 2.
A summary of some therapeutic inhibitors of ADAM17.
| Agent | Type of Agent | Disease Setting | Substrate Inhibited | Reference |
|---|---|---|---|---|
| INCB3619 | Small molecule inhibitor | Breast cancer and NSCLC | Heregulin | [182] |
| INCB7839 | Small molecule inhibitor | Breast cancer | HER2 | [183,184] |
| KP-457 | Small molecule inhibitor | Thrombus formation | Glycoprotein Ibα (GPIbα) | [185] |
| Prodomain | Peptide | LAC and inflammatory diseases | TNFα and IL-6R | [29,131,143] |
| D1(A12) | Antibody | Triple-negative breast cancer and head and neck squamous cell carcinoma | TNFα, TGFα, amphiregulin and TNFR1 | [174,186] |
| A9(B8) | Antibody | Pancreatic ductal adenoma | Amphiregulin | [180] |