Table 1.
The effect of β-carotene following the open field paradigm in mice that received i.c.v STZ.
| Parameters | Control | Disease (STZ) | β-Carotene | |||
|---|---|---|---|---|---|---|
| Dose mg/kg | CMC 1 mL/kg | 3.0 | 1.02 | 2.05 | ||
| Whole body movement | Latency (s.) | 2.80 ± 0.374 | 5.6 ± 0.510 | 3.20 ± 0.200 | 2.00 ± 0.316 | |
| Rearing (no.) | 27.40 ± 1.030 | 16.60 ± 0.245 | 39.60 ± 1.435 ** | 29.80 ± 9.749 | ||
| Freezing (s.) | 32.00 ± 1.225 *** | 89.00 ± 3.317 | 29.00 ± 1.789 *** | 16.00 ± 2.258 *** | ||
| Part body Movement | Scratching (s.) | 3.80 ± 0.97 *** | 5.40 ± 0.400 | 2.60 ± 0.400 *** | 1.20 ± 0.490 | |
| Teeth Chattering | No | Yes | No | No | ||
| Digging | No | Yes | No | No | ||
| Location | Field area Visited | Central (s.) | 52.40 ± 7.019 *** | 112.00 ± 16.778 | 30.20 ± 1.985 *** | 30.00 ± 3.146 *** |
| Peripheral (s.) | 209 ± 9.066 *** | 88.00 ± 3.742 | 235.0 ± 2.236 *** | 250.080 ± 15.203 *** | ||
| Crossing (no.) | 31.6 0 ± 0.927 *** | 16.30 ± 0.200 | 49.40 ± 631 *** | 16.00 ± 1.342 *** | ||
| ANS | Defecation (no.) | 2.60 ± 0.670 *** | 17.00 ± 0.447 | 0.60 ± 0.400 *** | 0.400 ± 0.245 *** | |
| Urination (no.) | 4.6 ± 0.400 *** | 10.00 ± 0.707 | 0.80 ± 0.374 *** | 0.200 ± 0.200 *** | ||
Data are represented as mean ± SEM, n = 10. (** P < 0.01), (**** P < 0.001) Significance was given in comparison to the disease group.