Table 2.
Overview of p21cip1/waf1 regulation by epigenetic erasers.
| Erasers | Epigenetic Mark | Experimental Conditions | p21cip1/waf1 Regulation | Ref. |
|---|---|---|---|---|
| TET | 5hmC | Glioma cells | Expression ↑ | [104] |
| KDM1A/LSD1 | H3K4/H3K9me | Renal cells carcinoma and glioma | Regulates p21cip1/waf1 via demethylation of histone and non-histone targets | [100,101] |
| HDAC | Histone deacetylation | Multiple myeloma and NSCLC | Expression ↑ | [105,106] |
TET—ten-eleven translocation; KDM1A/LSD1—lysine-specific (histone) demethylase 1; HDAC—histone deacetylases; 5hmC—5-hydroxymethylcytosine; H3K4/H3K9me—histone H3 lysine 4/histone H3 lysine 9 methylation; NSCLC—non-small cell lung cancer.