Figure 6.

Effect of quinolinic acid (QUIN) and curcumin (CUR) on the protein levels of the enzyme regulated by the nuclear factor erythroid 2-related factor 2 (Nrf2). Immunohistochemistry assays were performed at day 7 after the quinolinic acid (QUIN) injection. Representative photomicrographs (40×) of cells positive for glutathione peroxidase (GPx), glutathione reductase (GR), and γ-glutamylcysteine ligase, catalytic subunit (γ-GCLc) in the striatum are presented (A). Black arrows indicate cells positive for each protein. Boxes represent the magnified positive cells indicated by white arrows. Graphs indicate the percentage of cells positive for (B) GPx, (C) GR, and (D) γ-GCLc, counted in three randomly selected fields along the right striatum. Data are expressed as mean ± SEM (n = 5). * p < 0.05 and *** p < 0.001.