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NAD(P)H:quinone oxidoreductase (NQO1)-catalyzed redox cycling of TPZ. The rates of NQO1-catalyzed oxidation of NADPH (1,2), depletion of TPZ (3), and reduction of cytochrome c (4-7) in the presence of 300 µM NADPH. Additions: NADPH (1), NADPH + 300 µM TPZ (2,3), NADPH + 50 µM cytochrome c (4), NADPH +cytochrome c + 100 U/mL SOD (5), NADPH + TPZ + cytochrome c (6), NADPH + TPZ + cytochrome c + SOD (7), n = 3, p < 0.02 for 1 against 2 (*), for 4 against 5 (#), and 6 against 7 (**).
