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. 2019 Sep 17;20(18):4602. doi: 10.3390/ijms20184602

Figure 7.

Figure 7

Effects of cytochrome P-450 inhibitors on the cytotoxicity of quinones and ArN→O in MH22a cells. (A) Cell viability in the presence of 5.0 µM 9,10-phenanthrene quinone (1–4) and 50 µM tetramethyl-1,4-benzoquinone (5–8), additions: none (1,5), + 5.0 µM α-naphthoflavone (2,6), + 1.0 mM isoniazid (3,7), + 5.0 µM miconazole (4,8). n = 3, p < 0.01 for 1 against 2,3 (**), p < 0.02 for 1 against 4, and for 5 against 6–8 (*). (B) Cell viability in the presence of 10 µM 1,2,4-benzotriazine-1,4–dioxide (1-4) and 10 µM 7-F-TPZ (5–8), additions: none (1,5), + 5.0 µM α-naphthoflavone (2,6), + 1.0 mM isoniazid (3,7), + 5.0 µM miconazole (4,8). n = 3, p < 0.02 for 1 against 2–4, and for 5 against 6–8 (*). Additions of P-450 inhibitors did not affect the cell viability in control experiments, 98.5–99.3%.