Figure 3.

The correlation between global circRNAs levels and DM1 severity. (A) Listed are exemplary circRNAs which expression levels were found increased in skeletal muscles from DM1 patients [40]. Biomarkers of DM1 muscle severity, i.e., CTG repeat number, dominant grip, six-minute walk test and ankle dorsiflexion force are shown and the intensity of red and blue colors indicates, respectively, the level of positive and negative correlation. (B) Plots depicting the correlations of CTG repeat number, dominant grip, six-minute walk test and ankle dorsiflexion force are shown for exemplary circCPSF6 which global expression level (expressed as a fraction of circular particles, FCP) was found elevated in DM1 human muscle (for details please see Czubak et al. [40]).