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. 2019 Sep 6;20(18):4385. doi: 10.3390/ijms20184385

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CircGSE1 as an example of MBNL-regulated RNA. (A) Dot plot depicting a number of potential MBNL-binding sites in introns flanking circGSE1 (red dots) and 25 randomly selected circRNAs (black dots). The regions of flanking introns embracing 300 nt upstream and 300 nt downstream from circRNA-generating exons were used to determine a number of MBNL-binding sites. (B) The level of circGSE1 (expressed as read per million, RPM) is decreased in two types of skeletal muscles QF and TA from DM1 patients. (C) Localization of potential MBNL-binding sites (highlighted in yellow) in circGSE1 exon (blue font) and in 300-nt fragments of its flanking introns (black font) is shown in both human and mouse ortholog.