Table 2.
Results of the gene annotation: DAVID GO and pathway analysis (KEGG).
| Term | Count | p-Value | Genes |
|---|---|---|---|
| Biological process | |||
| GO:0006334: nucleosome assembly | 6 | 9.42 × 105 | HIST1H2BB, HIST1H1C, HIST1H1A, H2B, HIST1H3G, HIST1H3I |
| GO:0006335: DNA replication-dependent nucleosome assembly | 3 | 6.12 × 103 | H4, HIST1H3G, HIST1H3I |
| GO:0051290: protein heterotetramerization | 3 | 6.81 × 103 | H4, HIST1H3G, HIST1H3I |
| GO:0098792: xenophagy | 5 | 2.27 × 103 | TMEM39A, SNRPB2, CPA3, HIST1H3G, HIST1H3I |
| GO:0002230: positive regulation of defense response to virus by host | 5 | 3.68 × 103 | TMEM39A, SNRPB2, CPA3, HIST1H3G, HIST1H3I |
| GO:0046627: negative regulation of insulin receptor signaling pathway | 3 | 9.09 × 103 | PRKCD, KANK1, PRKCB |
| GO:0042742: defense response to bacterium | 4 | 1.63 × 102 | STAB1, FCGR1A, PRKCD, TMF1 |
| Cellular Components | |||
| GO:0000786: nucleosome | 7 | 1.60 × 105 | H4, HIST1H1C, HIST1H1A, H2B, HIST1H2AK, HIST1H3G, HIST1H3I |
| GO:0000788: nuclear nucleosome | 5 | 2.47 × 104 | HIST1H2BB, H2B, HIST1H3G, HIST1H3I |
| GO:0000784: nuclear chromosome, telomeric region | 4 | 2.3 × 102 | H4, TNKS, HIST1H3G, HIST1H3I |
| GO:0030176: integral component of endoplasmic reticulum membrane | 4 | 1.50 × 102 | PIGG, SARAF, MBOAT4, SLC27A2 |
| GO:0005615: extracellular space | 13 | 3.32 × 102 | A2M, H2B, HFE, FSTL1, CTSS, OVOS2, ESF1, VEGFC, GPI, CTSK, CPA3, CPB1, SMARCA4 |
| GO:0005788: endoplasmic reticulum lumen | 3 | 4.77 × 102 | EOGT, SLC27A2, POGLUT1 |
| Molecular Functions | |||
| GO:0046982: protein heterodimerization activity | 5 | 7.15 × 103 | AGTR1, HIST1H2BB, H4, H2B, FOXP1 |
| GO:0042393: histone binding | 3 | 3.67 × 102 | H4, PRKCB, SMARCA4 |
| KEGG Pathways | |||
| bta05322: Systemic lupus erythematosus | 9 | 7.64 × 108 | HIST1H2BB, H4, CD80, FCGR1A, HIST2H2BF, H2B, HIST1H2AK, HIST1H3G, HIST1H3I |
| bta05034: Alcoholism | 8 | 4.32 × 106 | HIST1H2BB, HRAS, H4, HIST2H2BF, H2B, HIST1H2AK, HIST1H3G, HIST1H3I |
| bta05203: Viral carcinogenesis | 5 | 1.92 × 103 | HIST1H2BB, HRAS, H4, HIST2H2BF, H2B |
| bta00514: Other types of O-glycan biosynthesis | 3 | 2.18 × 102 | ST6GAL2, EOGT, POGLUT1 |