Figure 5.

Receptors used by chemerin, visfatin, resistin and apelin for their signaling pathways. chemerin can bind three different receptors that are CMKLR1, GPR1 and CCRL2. CMKLR1 and GPR1 are coupled with intracellular Gαi proteins. The last receptor doesn’t have any active signaling pathway identified until now suggesting a putative role of co-receptor for CCRL2. Apelin has its own receptor called APJ coupled with intracellular Gq and Gαi proteins. Resistin could bind receptors such as CAP-1, ROR-1 and TLR-4 but it has to be confirmed. No receptor for visfatin has been identified until now.