Table 1.
SOX2 expression and function in glia and neurons.
| Glia | Sox2 Expression | Sox2 Function | References |
| Macroglia in the Central nervous system | |||
| Astrocytes | Yes | Cellular maturation and morphology (retina) | [21] |
| OPC and Oligodendrocytes | Yes | Proliferation, differentiation, myelination | [22,23,24,25] |
| Ependymal cells | Yes | Cellular structure (cilia reduction in Sox2 mutants) | [26] |
| Müller glia (retina) | Yes | Cellular structure and positioning | [27,28] |
| Bergmann glia (cerebellum) | Yes | Cellular morphology and positioning (in Sox2 mutants, defective motor control) | [29] |
| Macroglia in the peripheral nervous system | |||
| Schwann cells | Yes | Myelination | [30,31] |
| Satellite cells | Yes | Survival | [32,33] |
| Neurons | Sox2 Expression | Sox2 Function | References |
| Clock neurons in Suprachiasmatic nucleus | Yes | Regulation of circadian rhythms | [34] |
| Sensory thalamic nuclei (including DLG) | Yes | Signalling to incoming retinal axons; DLG growth; development of thalamic neurons projections to the visual and somatosensory cortex | [35] |
| Specific glutamatergic and cholinergic neurons in C. elegans | Yes | Differentiation of specific neuron-types | [36,37] |
| Cholinergic amacrine neurons | Yes | Cell positioning and dendritic stratification | [38] |
| GABA-ergic interneurons, rare pyramidal cells in the cortex | Yes | Morphology and maturation (impaired GABAergic neuroblast migration and differentiation; intraneuronal aggregates) |
[26,39] |
| Some striatal cells | Yes | N.A. | [26] |
| Thalamic cells | Yes | N.A. | [26] |