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. 2019 Sep 12;9(9):481. doi: 10.3390/biom9090481

Figure 4.

Figure 4

Syndecan-4 is implicated in LL-37 induced-calcium entry and cell migration. Effects of RNA interference against syndecan-1 and 4 on (a) LL-37-induced migration of MDA-MB-231, MDA-MB-435s and MCF7 (N = 5). (b) Calcium entry in MDA-MB-231, MDA-MB-435s cell lines induced by LL-37 (N = 3). (c) Immunofluorescence labeling with anti-LL-37 (Alexa488-green) on MDA-MB-231, treated with siRNA against syndecans-1 and 4. Nuclei labeled by DAPI (in blue). Magnification 400x. Data are normalized to the effects of LL-37. Statistics: ** p < 0.01, * p < 0.05.