Table 1.

PICO (Population, Intervention, Comparator, and Outcome) strategy and central seekers for regular studies.

Target	Description	Operator	Uniterms
Population	Healthy adults practicing physical activity	--	physical activity; physical exercise; training; exercise; coaching; resistance training; resistance exercise; gym; fitness; crossfit; weight lifting; non-sedentary; athlete.
		AND + NOT/AND NOT	child; pediatric; elder; aged; rat; mice.
Intervention	Whey protein supplementation (concentrated, hydrolyzed, and isolated)	AND	whey protein; whey; protein supplementation; whey supplementation; casein; casein supplementation; whey intake; casein intake; protein intake; whey concentrate; casein concentrate; concentrate protein; whey isolated; casein isolated; isolated protein; hydrolyzed whey; hydrolyzed casein; hydrolyzed protein; milk; milk protein; soy; soy protein.
Comparator	Randomized clinical trials	AND	controlled clinical trial; clinical trial; randomized clinical trial; group control; placebo; comparative study; cross-over; crossover; cross over; double-blind; factorial.
Outcome	Body composition related to hypertrophy	AND	muscle; mass gain; muscle gain; muscular gain; muscle strength; muscular strength; hypertrophy; lean mass; body composition; lean body mass; lean body tissue; fat-free mass; fat free mass; body weight; body mass; skeletal muscle.