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. 2019 Aug 23;11(9):1239. doi: 10.3390/cancers11091239

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Time trends of treatment in colon cancer (CC) and rectal cancer (RC) patients according to age group: (a) surgery in CC patients stages I–III, (b) chemotherapy in CC patients stage III, (c) surgery in RC patients stages I–III, (d) radiotherapy in RC patients stage III, (e) primary radiotherapy as a single treatment modality in RC patients stage III, and (f) chemoradiation in RC patients stages II–III. * Significant (p < 0.05) difference in treatment over time using the Cochran–Armitage trend test.