Table 2.
Multivariate Cox hazard analysis of five-year overall survival.
| Variable | BC | CRC | ||
|---|---|---|---|---|
| HR (95% CI) a | p | HR (95% CI) a | p | |
| Year of diagnosis (per year) | 0.98 (0.97–0.98) | <0.001 | 0.96 (0.96–0.97) | <0.001 |
| Age | <0.001 | <0.001 | ||
| 15–44 years | 1.04 (0.97–1.11) | 0.87 (0.76–0.98) | ||
| 45–54 years | 1.00 (ref) | 1.00 (ref) | ||
| 55–64 years | 1.35 (1.28–1.43) | 1.25 (1.17–1.34) | ||
| 65–74 years | 2.06 (1.95–2.18) | 1.81 (1.70–1.93) | ||
| ≥75 years | 4.89 (4.60–5.18) | 3.43 (3.22–3.65) | ||
| Gender | - | <0.001 | ||
| Male | - | 1.00 (ref) | ||
| Female | 0.82 (0.80–0.84) | |||
| Stage | <0.001 | <0.001 | ||
| I | 1.00 (ref) | 1.00 (ref) | ||
| II | 1.79 (1.72–1.87) | 1.50 (1.44–1.55) | ||
| III | 4.14 (3.96–4.32) | 2.74 (2.64–2.84) | ||
| Grade | <0.001 | <0.001 | ||
| Well differentiated | 1.00 (ref) | 1.00 (ref) | ||
| Moderately differentiated | 1.29 (1.22–1.35) | 1.02 (0.97–1.07) | ||
| Poorly differentiated and | 2.14 (2.03–2.25) | 1.46 (1.38–1.55) | ||
| undifferentiated | ||||
| Unknown | 1.67 (1.57–1.77) | 1.12 (1.06–1.19) | ||
| Surgery | <0.001 | <0.001 | ||
| No | 1.00 (ref) | 1.00 (ref) | ||
| Yes | 0.30 (0.28–0.32) | 0.14 (0.14–0.15) | ||
| Radiotherapy | <0.001 | <0.001 | ||
| No | 1.00 (ref) | 1.00 (ref) | ||
| Yes | 0.63 (0.61–0.65) | 0.76 (0.74–0.78) | ||
| Chemotherapy | <0.05 | <0.001 | ||
| No | 1.00 (ref) | 1.00 (ref) | ||
| Yes | 0.95 (0.90–0.99) | 0.64 (0.62–0.66) | ||
| Hormone therapy | <0.001 | |||
| No | 1.00 (ref) | - | ||
| Yes | 0.55 (0.53–0.57) | |||
a Adjusted for all variables included in the model. HR, hazard ratio. Significant (p < 0.05) HR values are indicated in bold. ref, reference 95% CI, 95% Confidence Interval.