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. 2019 Sep 13;11(9):1360. doi: 10.3390/cancers11091360

Figure 1.

Figure 1

Four patients with EGFR-mutated lung cancers and diffuse lung metastases. (A) 44-year-old female never-smoker presents with a central right hilar mass with mediastinal and right hilar lymphadenopathy and innumerable 2–3 mm pulmonary nodules bilaterally. Patient was subsequently diagnosed with non-small cell lung cancer (NSCLC) with EGFR exon 19 mutation. Note the air bronchograms in the primary tumor, a feature also described in EGFR-mutated NSCLC. (B) 66-year-old male never-smoker presents with a consolidative mass in the left upper lobe and lingula with miliary-like pattern of diffuse 2–3 mm pulmonary nodules bilaterally and mediastinal and left hilar lymphadenopathy. This patient was found to have NSCLC with EGFR exon 21 mutation. Again, note the air bronchogram in the primary tumor. (C) 74-year-old female never-smoker presenting with a dominant right upper lobe mass and diffuse innumerable 2–3 mm nodules bilaterally. Patient had an EGFR exon 19 mutation. (D) 61-year-old male never-smoker presents with diffuse 2–3 mm lung nodules with a dominant 2.3 cm left lower lobe spiculated nodule (not shown), which was positive for EGFR exon 19 mutation.