Table 4.
Functional annotation of target genes based on their enrichment in specific Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The top 25 most significant pathways are shown, which are targeted by at least two miRNA groups.
| Targets of All miRNA groups | Targets of Group 1 and Group 2 miRNAs | Targets of Group 2 and Group 3 miRNAs | Targets of Group 1 and Group 3 miRNAs |
|---|---|---|---|
| hsa04068:FoxO signaling pathway | hsa05213:Endometrial cancer | hsa04066:HIF-1 signaling pathway | hsa04110:Cell cycle |
| hsa04115:p53 signaling pathway | hsa04390:Hippo signaling pathway | hsa05206:MicroRNAs in cancer | hsa04012:ErbB signaling pathway |
| hsa04151:PI3K-Akt signaling pathway | hsa04722:Neurotrophin signaling pathway | hsa04621:NOD-like receptor signaling pathway | hsa04150:mTOR signaling pathway |
| hsa04152:AMPK signaling pathway | hsa04550:Signaling pathways regulating pluripotency of stem cells | hsa04917:Prolactin signaling pathway | |
| hsa04350:TGF-beta signaling pathway | hsa05202:Transcriptional misregulation in cancer | ||
| hsa04510:Focal adhesion | |||
| hsa04931:Insulin resistance | |||
| hsa05200:Pathways in cancer | |||
| hsa05205:Proteoglycans in cancer | |||
| hsa05230:Central carbon metabolism in cancer |